Body Weight Has Surprising, Alarming Impact on Brain Function

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Higher BMI is linked to decreased cerebral blood flow, which is associated with increased risk of Alzheimer’s disease and mental illness, according to a new study in JAD

Amsterdam, NL and Costa Mesa, CA, USA – As a person’s weight goes up, all regions of the brain go down in activity and blood flow, according to a new brain imaging study in the Journal of Alzheimer’s Disease. One of the largest studies linking obesity with brain dysfunction, scientists analyzed over 35,000 functional neuroimaging scans using single-photon emission computerized tomography from more than 17,000 individuals to measure blood flow and brain activity.

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Sucrose intake lowers μ-opioid and dopamine D2/3 receptor availability in porcine brain

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Average voxel-wise non-displaceable binding potential (BPND) maps superimposed on MRI images in sagittal view. Data are presented for [11C]carfentanil BPND of the 5 minipigs imaged at baseline, after initial exposure to sucrose and after 12 days of sucrose exposure (top row). [11C]carfentanil BPND of all 7 minipigs imaged at baseline and after 12 days of sucrose access are presented in the middle row. [11C]raclopride BPND of all 7 minipigs imaged at baseline and after 12 days of sucrose access are shown in the bottom row. Note that the color scale is exponential to highlight the [11C]raclopride BPND in extrastriatal regions.

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“Brasil enfrenta epidemia de demência”, afirma pesquisadora

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Um estudo realizado por pesquisadores da Faculdade de Medicina (FM) da USP indica que uma parcela significativa dos casos de demência diagnosticados no Brasil poderia ser evitada com o controle de doenças crônicas como hipertensão e obesidade. O que chamou a atenção dos pesquisadores foi que a proporção de demência do tipo vascular é maior no Brasil do que em outros países. O Jornal da USP no Ar conversou sobre esse assunto com a professora Cláudia Kimie Suemoto, da Disciplina de Geriatria e pesquisadora do Biobanco para Estudos em Envelhecimento da FMUSP. Ela também colabora com o Estudo Longitudinal da Saúde do Adulto (ELSA-Brasil).

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Exercise is more critical than diet to maintain weight loss

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“Our findings suggest that this group of successful weight-loss maintainers are consuming a similar number of calories per day as individuals with overweight and obesity but appear to avoid weight regain by compensating for this with high levels of physical activity,” said Victoria A. Catenacci, MD, a weight management physician and researcher at CU Anschutz Medical Campus.

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