Part of the brain that causes FEAR identified by scientists

People who are anxious about future threats may have an unusually large striatum, an area of the brain already associated with general anxiety disorder, according to new research.

In the study, 56 students had MRI scans taken of their brains after filling out a survey designed to measure their ability to tolerate the uncertainty of future negative events.

Analysis of the MRIs compared them with the intolerance of uncertainty scores and the scientists found the volume of the striatum was significantly associated with intolerance of uncertainty.

Professor Justin Kim, of Dartmouth College, said: “Uncertainty and ambiguity of potential future threats are central to understanding the generation of anxiety and anxiety disorders.

“Our research suggests a relationship between an individual’s ability to deal with this uncertainty and the volume of gray matter within a specific area of the brain.

 

“People who had difficulty tolerating an uncertain future had a relatively enlarged striatum.

People who had difficulty tolerating an uncertain future had a relatively enlarged striatum

Professor Justin Kim

“What surprised us was that it was only the striatum and not other parts of the brain we examined.”

Previous studies focusing specifically on patients with obsessive compulsive disorder and general anxiety disorder have also found increased gray matter volumes in the striatum, but this is the first time it has been found in association with intolerance of uncertainty in the absence of a confirmed diagnosis, according to professor Kim.

He added: “Our findings demonstrate that the relationship between increased striatal volumes and intolerance of uncertainty can be observed in healthy individuals.

“Having a relatively enlarged volume of the striatum may be associated with how intolerant you are when facing an uncertain future, but it does not mean you have OCD or generalised anxiety disorder.

Ancious

Scientist have discovered that people who’re anxious may have unusually large striatum

“To put it another way, the striatum encodes how predictable and expected a reward is – a higher form of reward processing compared to simply responding to a reward.

“Given that an important component of intolerance of uncertainty is a desire for predictability, our findings offer a biological marker related to our need for predictability.”

While the striatum has been primarily known for its role in motor function, animal studies have also suggested that it plays a role in how we predict whether or not we will receive a reward for a particular behaviour while learning new tasks, according to Prof Kim.

MRI scan

In the study 56 students had MRI scans of their brains and filled out a survey

Since the findings came from psychologically healthy subjects, Professor Kim suggested that that the volume of the striatum in young adults could predict those at risk for developing anxiety disorder or OCD later in life.

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