The flavonoid cyanidin blocks binding of the cytokine interleukin-17A to the IL-17RA subunit to alleviate inflammation in vivo

captura-de-pantalla-2017-02-26-a-las-11-37-33

How red berries reduce inflammation

Members of the interleukin-17 (IL-17) family of proinflammatory cytokines are important in the immune response to infections; however, excessive IL-17 signaling is associated with autoimmune inflammatory diseases, such as asthma, psoriasis, and rheumatoid arthritis. Through a screen of small molecules, Liu et al. found that cyanidin, a flavonoid found in red berries and other fruits, bound to the IL-17 receptor (IL-17RA) in a manner that blocked the binding of IL-17A. In several mouse models of inflammatory disease, cyanidin alleviated inflammation induced by T cells that produce IL-17A. Together, these data suggest that cyanidin should be further developed as a small-molecule inhibitor of IL-17A–dependent inflammatory diseases.

Leer Más


“Que yo nunca rece para ser preservado de los peligros: sino para alzarme ante ellos y mirarlos cara a cara.

Que no pida la extinción de mi dolor: sino el coraje que me falta para sobreponerme a él.

Que no confíe en aliados en la guerra de la vida sobre el campo de batalla del alma: que sólo espere de mí.

Que no implore, espantado, mi salvación: que tenga la fe necesaria para conquistarla.

Dame no ser ingrato: pues a tu misericordia debo mis triunfos.

Y si sucumbo, acude a mí con tu brazo fuerte. ¡Y dame la paz, y dame la guerra!”

Oración Rabindranath Tagore


Scientists identify mechanisms driving gut bacterial imbalance and inflammation

Date:February 8, 2017
Source:UT Southwestern Medical Center
Summary:A study has uncovered key molecular pathways behind the disruption of the gut’s delicate balance of bacteria during episodes of inflammatory disease.
FULL STORY

 A study led by UT Southwestern Medical Center researchers has uncovered key molecular pathways behind the disruption of the gut’s delicate balance of bacteria during episodes of inflammatory disease.

“A deeper understanding of these pathways may help in developing new prevention and treatment strategies for conditions such as inflammatory bowel disease (IBD) and certain gastrointestinal infections and colorectal cancers,” said Dr. Sebastian Winter, Assistant Professor of Microbiology and a W.W. Caruth, Jr. Scholar in Biomedical Research at UT Southwestern, who led the study.

More than 1 million people in the U.S. suffer from IBD, a chronic, lifelong inflammatory disorder of the intestines that has no cure or means of prevention.

Leer Más


Fasting For Just Five Days A Month Linked To Health Improvements

Participants lowered their body mass index, blood pressure, blood sugar and cholesterol.

JGI/JAMIE GRILL VIA GETTY IMAGES

Dr. Min Wei of UCLA’s Longevity Institute and colleagues tested the effects of the fasting-mimicking diet on various risk factors for diabetes, heart disease, cancer or other conditions.

The diet (FMD; brand name ProLon) is low in calories, sugars and protein but high in unsaturated fats. Forty-eight study participants ate normally for three months while 52 ate FMD for five days each month and ate normally the rest of the time. After three months, the groups switched regimens. Although all participants were considered healthy, some had high blood pressure, low levels of “good” cholesterol, and other risk factors.

A total of 71 people completed the study, which was published in Science Translational Medicine. Body mass index, blood pressure, blood sugar and cholesterol improved with FMD, but mainly for those who were already at risk. Side effects were mild, including fatigue, weakness and headaches.

Leer Más


Lose weight, improve your vision, and more with… the placebo effect!

You probably associate the placebo effect with sugar pills. But according to these studies, the placebo effect is way more powerful than that: in fact, it can affect everything from weight loss to visual acuity. In the first study, hotel housekeepers who were told that their work was good exercise actually lost weight compared to a control group, even though their behavior did not change. In the second study, participants’ visual acuity improved when they simply acted as pilots (who they were told have good vision) in a flight simulator. And in the third study, diabetics’ blood sugar was more affected by how much time they *thought* had passed since their last meal, as opposed to how much time had actually passed. Talk about mind over matter!

Leer Más



Bill Gates, Warren Buffett And Oprah All Use The 5-Hour Rule

Top business leaders often spend five hours per week doing deliberate learning.

In the article “Malcolm Gladwell got us wrong”, the researchers behind the 10,000-hour rule set the record straight: different fields require different amounts of deliberate practice in order to become world class.

If 10,000 hours isn’t an absolute rule that applies across fields, what does it really take to become world class in the world of work?

Over the last year, I’ve explored the personal history of many widely-admired business leaders like Elon Musk, Oprah Winfrey, Bill Gates, Warren Buffett and Mark Zuckerberg in order to understand how they apply the principles of deliberate practice.

What I’ve done does not qualify as an academic study, but it does reveal a surprising pattern.

Many of these leaders, despite being extremely busy, set aside at least an hour a day (or five hours a week) over their entire career for activities that could be classified as deliberate practice or learning.

I call this phenomenon the 5-hour rule.

Leer Más


Bill Gates, Warren Buffett And Oprah All Use The 5-Hour Rule

Top business leaders often spend five hours per week doing deliberate learning.

In the article “Malcolm Gladwell got us wrong”, the researchers behind the 10,000-hour rule set the record straight: different fields require different amounts of deliberate practice in order to become world class.

If 10,000 hours isn’t an absolute rule that applies across fields, what does it really take to become world class in the world of work?

Over the last year, I’ve explored the personal history of many widely-admired business leaders like Elon Musk, Oprah Winfrey, Bill Gates, Warren Buffett and Mark Zuckerberg in order to understand how they apply the principles of deliberate practice.

What I’ve done does not qualify as an academic study, but it does reveal a surprising pattern.

Many of these leaders, despite being extremely busy, set aside at least an hour a day (or five hours a week) over their entire career for activities that could be classified as deliberate practice or learning.

I call this phenomenon the 5-hour rule.

How the best leaders follow the 5-hour rule

For the leaders I tracked, the 5-hour rule often fell into three buckets: reading, reflection, and experimentation.

1. Read

According to an HBR article, “Nike founder Phil Knight so reveres his library that in it you have to take off your shoes and bow.”

Oprah Winfrey credits books with much of her success: “Books were my pass to personal freedom.” She has shared her reading habit with the world via her book club.

These two are not alone. Consider the extreme reading habits of other billionaire entrepreneurs:

Want to read the most-recommended books by top leaders like Bill Gates, Mark Zuckerberg, Sheryl Sandberg, and Elon Musk? I created a report that highlights the 460 most-recommended books of 60 top CEOs, entrepreneurs, and leaders.

2. Reflect

Other times, the 5-hour rule takes the form of reflection and thinking time.

AOL CEO Tim Armstrong makes his senior team spend four hours per weekjust thinking. Jack Dorsey is a serial wanderer. LinkedIn CEO Jeff Weiner schedules two hours of thinking time per day. Brian Scudamore, the founder of the 250 million-dollar company, O2E Brands, spends 10 hours a week just thinking.

When Reid Hoffman needs help thinking through an idea, he calls one of his pals: Peter Thiel, Max Levchin, or Elon Musk. When billionaire Ray Dalio makes a mistake, he logs it into a system that is public to all employees at his company. Then, he schedules time with his team to find the root cause. Billionaire entrepreneur Sara Blakely is a long-time journaler. In one interview, she shared that she has over 20 notebooks where she logged the terrible things that happened to her and the gifts that have unfolded as a result.

If you want to be in to company of others who reflect on what they’re learning with each other, join this Facebook group.

3. Experiment

Finally, the 5-hour rule takes the form of rapid experimentation.

Throughout his life, Ben Franklin set aside time for experimentation, masterminding with like-minded individuals, and tracking his virtues. Google famously allowed employees to experiment with new projects with 20% of their work time. Facebook encourages experimentation through Hack-A-Months.

The largest example of experimentation might be Thomas Edison. Even though he was a genius, Edison approached new inventions with humility. He would identify every possible solution and then systematically test each one of them. According to one of his biographers, “Although he understood the theories of his day, he found them useless in solving unknown problems.”

He took the approach to such an extreme that his competitor, Nikola Tesla, had this to say about the trial-and-error approach: “If [Edison] had a needle to find in a haystack, he would not stop to reason where it was most likely to be, he would proceed at once with the feverish diligence of the bee to examine straw after straw until he found the object of his search.”

The power of the 5-hour rule: improvement rate

People who apply the 5-hour rule in the world of work have an advantage. The idea of deliberate practice versus just working hard is often confused. Also, most professionals focus on productivity and efficiency, not improvement rate. As a result, just five hours of deliberate learning a week can set you apart.

Billionaire entrepreneur Marc Andreessen poignantly talked about improvement rate in a recent interview. “I think the archetype/myth of the 22-year-old founder has been blown completely out of proportion… I think skill acquisition, literally the acquisition of skills and how to do things, is just dramatically underrated. People are overvaluing the value of just jumping into the deep-end of the pool, because like the reality is that people who jump into the deep end of the pool drown. Like, there’s a reason why there are so many stories about Mark Zuckerberg. There aren’t that many Mark Zuckerbergs. Most of them are still floating face down in the pool. And so, for most of us, it’s a good idea to get skills.”

Later in the interview he adds, “The really great CEOs, if you spend time with them, you would find this to be true of Mark [Zuckerberg] today or of any of the great CEOs of today or the past, they are really encyclopedic of their knowledge of how to run a company, and it’s very hard to just intuit all of that in your early 20s. The path that makes much more sense for most people is to spend 5–10 years getting skills.”

We should look at learning like we look at exercise.

We need to move beyond the cliche, “Life-long learning is good,” and think more deeply about what the minimum amount of learning the average person should do per day in order to have a sustainable and successful career.

Just as we have minimum recommended dosages of vitamins, steps per day, and aerobic exercise for leading a healthy life physically, we should be more rigorous about how we as an information society think about the minimum doses of deliberate learning for leading a healthy life economically.

The long-term effects of NOT learning are just as insidious as the long-term effects of not having a healthy lifestyle. The CEO of AT&T makes this point loud and clear in an interview with the New York Times; he says that those who don’t spend at least 5 to 10 hours a week learning online “will obsolete themselves with technology.”

 — — —

Link original: https://medium.com/@michaeldsimmons/8e564aa185ac#.tr6dgtv7p